Severe asthma: Can we fix it? Prologue to seeking innovative solutions for severe asthma

Is it severe asthma or asthma with severe comorbidities?

Severe asthma is defined as asthma that requires treatment with high-dose inhaled corticosteroids (ICSs) plus a second controller and/or systemic corticosteroids to prevent it from becoming uncontrolled or that remains uncontrolled despite this therapy. This definition has limitations: 1) it does not define any biological characteristic that distinguishes severe asthma from asthma in general an...

[Severe asthma].

Severe asthma and allergy - should we look for the allergens

Material and method For a period of 6 months we evaluated medical history data of 29 children with asthma divided into two groups 14 (6 girls, 8 boys) with severe asthma (SA) on high dose combined inhaled corticosteroids (ICS) and 15 (6 girls, 9 boys) with moderate asthma, matched by age to serve as a control group. For all children we performed pulmonary function tests (PFT), nasal smears for ...

Guidelines for severe uncontrolled asthma.

Since the publication, 9 years ago, of the latest SEPAR (Spanish Society of Pulmonology and Thoracic Surgery) Guidelines on Difficult-to-Control Asthma (DCA), much progress has been made in the understanding of asthmatic disease. These new data need to be reviewed, analyzed and incorporated into the guidelines according to their level of evidence and recommendation. Recently, consensus document...

Emerging therapies for severe asthma

Many patients with asthma have poorly controlled symptoms, and particularly for those with severe disease, there is a clear need for improved treatments. Two recent therapies licensed for use in asthma are omalizumab, a humanized monoclonal antibody that binds circulating IgE antibody, and bronchial thermoplasty, which involves the delivery of radio frequency energy to the airways to reduce air...